联系方式
办公室：深圳研究生院E栋204室
电子邮箱：yuke.sz@pku.edu.cn
个人简介
余珂，博士，就职于北京大学深圳研究生院，任研究员、助理教授、北京大学环境科学与工程学、计算机应用技术双学科博导，同时兼任Microbiome杂志高级编辑（Senitor Editor）、iMeta等杂志编委。他的研究关注于从极端环境，尤其是从极端环境（盐碱水生态系统）中发掘未知的微生物类群，以期发现人类未知的潜在功能性微生物或生物活性物质的合成基因组簇，并将其进行培育或生物合成。为达到这一目的，他致力于开发基于分子生物学技术及人工智能技术的微生物组技术与生物信息学研究方法，专注于宏基因组和宏转录组的分析算法、数据库、分析流程及可视化系统开发，结合代谢组、培养组及基因操作技术，实现对来源于各种环境及人体，尤其是极端环境体系中，具有应用潜力的微生物及生物合成基因簇的识别与培育。主持国家自然科学基金面上基金及青年基金，以单位第一负责人参与国家自然科学基金重点基金及“十四五”国家重点研发计划项等15项课题，经费总额为800多万人民币。成果包括以第一作者或通讯作者身份在包括Nature Communications、Microbiome、Environmental Science & Technology、Water Research等多种综合性、微生物学、环境科学及工程类期刊的多篇SCI论文，总SCI论文数合为90余篇，总引用次数5000余次。其中，以第一作者发表的世界上首篇应用宏转录组技术解析活性污泥微生物的论文，被丹麦奥尔本大学的世界污水处理微生物的权威专家Per H Nielsen教授上评为近50年来解析活性污泥微生物生态的20篇里程碑式研究技术型论文之一；另一篇多宏组学技术论文被佐治亚理工大学的著名分子生物学及细胞生物学讲席教授Marvin Whiteley评价为革新了菌间互作研究的方法，为未来研究提供了崭新的途径。
教育与工作经历
2023.6-至今，北京大学，环境工程、计算机应用科学，双学科博导；
2016.7-至今，北京大学环境与能源学院，助理教授，环境工程博导；
2014-2016，加州大学伯克利分校，博士后；
2010-2014，香港大学工学院环境工程，博士；
学术兼职
2024.8-至今，Microbiome杂志，高级编辑（Senitor Editor）
2022.8-至今，iMeta杂志，编委
研究方向
研究关注于极端环境及人体系统的微生物，开发
1）痕量遗传物质富集及测序技术
2）基于人工智能技术的多宏组软件、算法及分析流程开发
3）多组学高精度数据解析和定向富集培养技术，以此发掘地球演化过程中的特殊微生物类群及其在特殊生物制剂生产、环境修复与改造中的应用潜能
拟招生方向
以水环境科学与工程方向招生，每年招收约一名博士生及二至四名硕士生。主要招生相关专业（但不限于以下）：生命科学类学科、环境科学与工程类、计算机及应用数学。
教授课程
秋季：数据可视化与分析方法
春季：环境生物信息学方法
科研项目
1. 2025-2028，基于多宏组学数据及深度学习模型构建原核微生物的全局操纵子序列数据库及其应用，国家自然科学基金面上基金项目（项目编号32470697），主持；
2. 2021-2026，代谢调控导向的微生物组-宿主-药物互作网络与信号传递机理，国家重点研发计划“生物大分子与微生物组”重点专项（项目编号2021YFA1301300），子课题负责人；
3. 2020-2024，黄河甘宁蒙段典型污染物对鱼类生存繁衍的潜在影响及参与生态流量研究，国家自然科学基金重点项目（项目编号：51939009），协助单位负责人；
4. 2018-2020，基于多维组学技术解译厌氧氨氧化细菌对亚硝酸盐胁迫与分子氧胁迫响应的分子机制，国家自然科学基金青年科学基金项目（项目编号51709005），主持。
5. 2024-2026，基于深度学习模型预测原核生物操纵子完整功能结构，北京大学科学智能（AI4S）交叉研究专项，主持。
研究成果
以第一作者或通讯作者身份在包括Nature Communications、Microbiome、Environmental Science & Technology、Water Research等多种综合性、微生物学、环境科学及工程类期刊的多篇SCI论文，总SCI论文数合为90余篇，总引用次数5000余次。其中，以第一作者发表的世界上首篇应用宏转录组技术解析活性污泥微生物的论文，被丹麦奥尔本大学的世界污水处理微生物的权威专家Per H Nielsen教授上评为近50年来解析活性污泥微生物生态的20篇里程碑式研究技术型论文之一；另一篇多宏组学技术论文被佐治亚理工大学的著名分子生物学及细胞生物学讲席教授Marvin Whiteley评价为革新了菌间互作研究的方法，为未来研究提供了崭新的途径。以下为部分代表论文(*:通讯作者; #: 第一作者)：
（1） Z Qiu#, L Yuan, C Lian, B Lin, J Chen, R Mu, X Qiao, L Zhang, Z Xu, Lu Fan, Yunzeng Zhang, Shanquan Wang, Junyi Li, Huiluo Cao, Bing Li, Baowei Chen, Chi Song, Yongxin Liu, Lili Shi, Yonghong Tian, Jinren Ni, Tong Zhang, Jizhong Zhou, Wei-Qin Zhuang, K Yu#*. BASALT refines binning from metagenomic data and increases resolution of genome-resolved metagenomic analysis. Nature Communications, 2024, 15: 2179.
（2） R Keren#, J Lawrence#, W Zhuang, D Jenkins, J Banfield, L Alvarez-Cohen, L Zhou*, K Yu*. Increased replication rates of dissimilatory nitrogen-reducing bacteria leads to decreased anammox reactor performance. Microbiome, 2020, 8:6.
（3） K Yu*#, S Yi#, B Li, F Guo, X Peng, Z Wang, Y Wu, L Alvarez-Cohen and T Zhang*. An integrated meta-omics approach reveals substrates involved in synergistic interactions in a bisphenol A (BPA)- degrading microbial community. Microbiome, 2019, 7: 16.
（4） C Deng#, T Chen#, Z Qiu, H Zhou, B Li, Y Zhang, X Xu, CA Lian, X Qiao, K Yu*. A mixed blessing of influent leachate microbes in downstream biotreatment systems of a full-scale landfill leachate treatment plant. Water Research, 2024, 253: 121310.
（5） Y Geng#, Z Xiong, L Yang*, CA Lian, S Pavlostathis, Z Qiu, H Chen, Q Luo, Y Liu, Z Liu, P Shao, J Zou, H Jiang, S Luo, K Yu*, X Luo*, Bidirectional enhancement of nitrogen removal by indigenous synergetic microalgal–bacterial consortia in harsh low-C/N wastewater. Environmental Science & Technology, 2024, 58 (12), 5394-5404.
（6） Z Qiu#, S He#, C Lian, Q Zhang, X Qiao, C Yao, R Mu, L Wang, X Cao, Y Yan, K Yu*. Large scale exploration reveals rare taxa as key members shaping microbial assembly in alkaline lake sediments. npj Biofilms & Microbiomes, 2024, 10:62.
（7） X Qiao#, L Ding, F Fang, C Fu, R Wei, Y Chen, S Zheng, X Wang, Y Yan, K Yang, N Xu, H Tao, K Yu*, L Zhang*. An integrated meta-omics approach reveals the different response mechanisms of two anammox bacteria towards fluoroquinolone antibiotics, Environmental International, 2024, 185: 108505.
（8） Y Geng#, C Lian, L Yang, S Pavlostathis, Z Qiu, X Qiao, Z Xiong, N Dong, J Hu, X Luo, K Yu*, Self-adaptation of tolerant microalgae-bacterial consortia in landfill leachate: Simultaneous achievement of efficient nitrogen removal and value-added utilization, Chemical Engineering Journal, 2025, 504, 158912.
（9） Z Qiu#, Y Zhu, Q Zhang, X Qiao, R Mu, Z Xu, Y Yan, F Wang, T Zhang, K Yu*. Unravelling Biosynthesis and Biodegradation Potentials of Microbial Dark Matters in Hypersaline Lakes. Environmental Science and Ecotechnology, 2024, 20: 100359.
（10） X Qiao#, L Zhang, T Yuan, Y Wu, W Zhuang, K Yu*, Mixotrophic anammox bacteria outcompete dissimilatory nitrate reduction and denitrifying bacteria in wastewater with propionate. Bioresource Technology, in press.
（11）C Deng#, R Zhao, Z Qiu, B Li*, T Zhang, F Guo, R Mu, Y Wu, X Qiao, L Zhang, J Cheng, J Ni, K Yu*. Genome-centric metagenomics provides new insights into the microbial community and metabolic potential of landfill leachate microbiota. Science of the Total Environment, 2022, 816: 151635.
（12）H Liang#, F Wang#, R Mu, J Huang, R Zhao, X Li, K Yu*, B Li*. Metagenomics analysis revealing the occurrence of antibiotic ressistome in salt lakes. Science of the Total Environment, 2021, 790: 148262.
（13）YGeng*, L Yang, C Lian, S G. Pavlostathis, Z Qiu, Z Xiong, Y Liu, B Li, J Hu, W Fan, X Luo, K Yu*. Resourceful application and mechanism of oyster shell-microalgae synergistic system: Sustainable treatment of harsh low carbon nitrogen ratio actual wastewater. Environmental Research, 2024, 252: 118775.
（14） L Wang#, C Lian, W Wan, Z Qiu, X Luo, Q Huang, Y Deng, T Zhang, K Yu*. Salinity-triggered homogeneous selection constrains the microbial function and stability in lakes. Applied Microbiology and Biotechnology, 2023, 1-15.
（15） Z Wang#, W Song#, X Zhang#, M Zheng, H Li, K Yu*, F Guo*. Expanding the Diversity of Accumulibacter with a Novel Type and Deciphering the Transcriptional and Morphological Features among Co-Occurring Strains. Applied and Environmental Microbiology, 2023, 89 (8), e00771-23
（16）X Qiao#, L Zhang, Z Qiu, L Wang, Y Wu, C Deng, J Su, X Zhang, Y Wang, B Li, L Zhou, A Ma, W Zhuang, K Yu*. Specific Denitrifying and Dissimilatory Nitrate Reduction to Ammonium Bacteria Assisted the Recovery of Anammox Community From Nitrite Inhibition. Frontiers in Microbiology, 2021, 781156.
（17） J Liu#, H Shi#, K Yu*, Y Geng, X Hu, G Yi, J Zhang, X Luo*. Regeneration and reuse of anode graphite from spent lithium-ion batteries with low greenhouse gas (GHG) emissions. Chinese Chemical Letters, 2023, 108274.
（18） H Zhou#, K Yu#, C Deng, B Wu, Y Gao*. Deterministic processes influence bacterial more than fungal community assembly during the development of biological soil crusts in the desert ecosystem. Frontiers in Microbiology, 2024,15: 1404602.
（19） W Cai#, K Yu#, W Yang, R Mu, C Lian, L Xie, Y Yan, S Liao, F Wang*. Prokaryotic Community Structure, Abundances, and Potential Ecological Functions in a Mars Analog Salt Lake. Astrobiology, 2023, 23 (5), 550-562.
（20） C Xie#, K Yu#, Y Yin, L Wang, Z Qiu, H Qin*. Abundance, diversity and changes to environmental variables of comammox Nitrospira in bioretention system. Journal of Water Process Engineering, 2023, 51: 103411.
（21） L Zhou#*, Y Gao#, K Yu#, H Zhou, Y Costa, S Yi, W Zhuang. Microbial community in in-situ waste sludge anaerobic digestion with alkalization for enhancement of nutrient recovery and energy generation. Bioresource Technology, 2020, 295: 122277.
（22）Y Wu#, Y Wang, Y. De Costa, Z Tong, J Cheng, L Zhou, W Zhuang*, K Yu*. The co-existence of anammox genera in an expanded granular sludge bed reactor with biomass carriers for nitrogen removal. Applied Microbiology and Biotechnology, 2019, 103, 1231-1242.
（23）K Yuan#, K Yu#, R Yang, Q Zhang, Y Yang, T Luan, W Chen, B Chen*. Metagenomic characterization of antibiotic resistance genes in Antarctic soils. Ecotoxicology and Environmental Safety, 2019, 176, 300-308.
（24）Y Men*#, K Yu#, J Bælum, Y Gao, J Tremblay, E Prestat, B Stenuit, S Tringe, J Jansson, T Zhang, and L Alvarez-Cohen. Metagenomic and metatranscriptomic analyses reveal structure and dynamics of a dechlorinating community containing Dehalococcoides mccartyi and corrinoid-providing microorganisms under cobalamin-limited condition. Applied and Environmental Microbiology, 2017, 83(8): e03508-16.
（25）K Yu#, T Zhang. Construction of customized sub-databases from NCBI-nr database for rapid annotation of huge Metagenomic datasets using a combined BLAST and MEGAN approach. PLoS ONE, 2013, 8(4): e59831.
（26）C Lianguo#, Y Ke#, H Changjiang, Y Liqin, Z Bingqing, L Paul, L James, B Zhou*. Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. Environmental Science & Technology, 2012, 46, 9727-9734.
（27）K Yu#, B Li, T Zhang*. Direct rapid analysis of multiple PPCPs in municipal wastewater using ultrahigh performance liquid chromatography-tandem mass spectrometry without SPE pre-concentration. Analytica Chimica Acta., 2012, 738, 59-68.
（28）K Yu#, T Zhang*. Metagenomic and metatranscriptomic analysis of microbial community structure and gene expression of activated sludge. PLoS ONE, 2012, 7(5): e38183.
（29）K Yu#, Y He, L Yeung, P Lam, R Wu, B Zhou*. DE-71-induced apoptosis involving intracellular calcium and the Bax-mitochondria-caspase protease pathway in human neuroblastoma cells in vitro. Toxicological Sciences, 2008, 104, 341-351.
（30）C White#, E Antell#, S Schwartz, J Lawrence, R Keren, L Zhou, K Yu, W Zhuang, L Alvarez-Cohen*. Life history strategies determine response to SRT driven crash in anammox bioreactors. Water Research, 2025, 122727.
（31）T Chen, C Deng, S Li, B Li, Y Liang, Y Zhang, J Li, N Xu, K Yu. Multi-omics illuminates the functional significance of previously unknown species in a full-scale landfill leachate treatment plant. Journal of Hazardous Materials, 2024, 479:5, 135669.
（32）H Chu, W Li, D Han, K Yu, Y Liu, et al.. The Microbiome Protocols eBook initiative: Building a bridge to microbiome research. iMeta, 2024, 3:2.
（33） B Pan, X Han, K Yu, H Sun, R Mu, CA Lian. Geographical distance, host evolutionary history and diet drive gut microbiome diversity of fish across the Yellow River. Molecular Ecology, 2023, 32 (5), 1183-1196.
（34） X Qiao, C Fu, Y Chen, F Fang, Y Zhang, L Ding, K Yang, B Pan, N Xu, K Yu. Molecular insights into enhanced nitrogen removal induced by trace fluoroquinolone antibiotics in an anammox system. Bioresource Technology, 2023, 374, 128784.
（35） S Zhang, L Yan, J Cao, K Wang, Y Luo, H Hu, L Wang, R Yu, B Pan, K Yu etc. Salinity significantly affects methane oxidation and methanotrophic community in Inner Mongolia lake sediments. Frontiers in Microbiology, 2023, 13, 1067017.
（36） C Jia, L Wu, K Yu, J Hu, JW Qi, A Luo. Achieving stable anammox process and revealing shift of bacteria during the start‐up in landfill leachate treatment. Water Environment Research, 2023, 95 (2), e10841.
（37） C White, E Antell, SL Schwartz, JE Lawrence, R Keren, L Zhou, K Yu etc. Synergistic interactions between anammox and dissimilatory nitrate reducing bacteria sustains reactor performance across variable nitrogen loading ratios. Frontiers in Microbiology, 2023, 14.
（38） Y Wu, S Li, K Yu, J Hu, Q Chen, W Sun. Wastewater treatment plant effluents exert different impacts on antibiotic resistome in water and sediment of the receiving river: Metagenomic analysis and risk assessment. Journal of Hazardous Materials, 2023, 132528.
（39） T Chen, C Deng, Z Wu, T Liu, Y Zhang, X Xu, X Zhao, J Li, S Li, N Xu, K Yu. Metagenomic analysis unveils the underexplored roles of prokaryotic viruses in a full-scale landfill leachate treatment plant. Water Research, 2023, 120611.
（40） R Li, J Huang, C Liu, K Yu, F Guo, Y Li, Z Chen, X Wang, R Zhao, J Zhang etc. Genome-centric metagenomics provides new insights into metabolic pathways of polyhydroxyalkanoates biosynthesis and functional microorganisms subsisting on municipal organic wastes. Water Research, 2023, 244, 120512.
（41） X Dong, K Yu, X Jia, Y Zhang, X Peng. Perchlorate reduction kinetics and genome-resolved metagenomics identify metabolic interactions in acclimated saline lake perchlorate-reducing consortia. Water Research, 2022, 227, 119343.
（42） J Zhang, X Li, U Klümper, H Lei, TU Berendonk, F Guo, K Yu, C Yang, B Li. Deciphering chloramphenicol biotransformation mechanisms and microbial interactions via integrated multi-omics and cultivation-dependent approaches. Microbiome, 2022, 10 (1), 1-19.
（43） L Wu, C Jia, S Huang, K Yu, A Luo, Y Peng. Nitrite oxidation in oxygen-deficient conditions during landfill leachate treatment. Environmental Research, 2022, 214, 114090.
（44） R Hu, H Zhao, X Xu, Z Wang, K Yu, L Shu, Q Yan, B Wu, C Mo, Z He, etc. Bacteria-driven phthalic acid ester biodegradation: Current status and emerging opportunities. Environment International, 2021,154, 106560.
（45） L Zhou, P Ou, B Zhao, W Zhang, K Yu, K Xie, WQ Zhuang. Assimilatory and dissimilatory sulfate reduction in the bacterial diversity of biofoulant from a full-scale biofilm-membrane bioreactor for textile wastewater treatment. Science of The Total Environment, 2021, 772, 145464.
（46） W Wang, J Tao, K Yu, C He, J Wang, P Li, H Chen, B Xu, Q Shi, C Zhang. Vertical stratification of dissolved organic matter linked to distinct microbial communities in subtropic estuarine sediments. Frontiers in Microbiology, 2021, 12, 697860.
（47） J Zhou, BY Zhang, K Yu, XP Du, JM Zhu, YH Zeng, ZH Cai. Functional profiles of phycospheric microorganisms during a marine dinoflagellate bloom. Water Research, 2020,173, 115554.
（48） R Zhao, K Yu, J Zhang, G Zhang, J Huang, L Ma, C Deng, X Li, B Li. Deciphering the mobility and bacterial hosts of antibiotic resistance genes under antibiotic selection pressure by metagenomic assembly and binning approaches. Water Research, 2020, 186, 116318.
（49） J Zhang, W Gan, R Zhao, K Yu, H Lei, R Li, X Li, B Li. Chloramphenicol biodegradation by enriched bacterial consortia and isolated strain Sphingomonas sp. CL5. 1: the reconstruction of a novel biodegradation pathway. Water Research, 2020, 187, 116397.
（50） X Mao, B Stenuit, J Tremblay, K Yu, SG Tringe, L Alvarez-Cohen. Structural dynamics and transcriptomic analysis of Dehalococcoides mccartyi within a TCE-Dechlorinating community in a completely mixed flow reactor. Water Research, 2019, 158, 146-156.
（51） A Lavy, R Keren, K Yu, BC Thomas, L Alvarez‐Cohen, J Banfield, M Ilan. A novel Chromatiales bacterium is a potential sulfide oxidizer in multiple orders of marine sponges. Environmental Microbiology, 2018, 20 (2), 800-814.
（52） G Zhang, B Li, J Liu, M Luan, L Yue, XT Jiang, K Yu, Y Guan. The bacterial community significantly promotes cast iron corrosion in reclaimed wastewater distribution systems. Microbiome, 2018, 6, 1-18.
（53） X Liu, Y Wu, FP Wilson, K Yu, C Lintner, A Cupples, TE Mattes. Integrated methodological approach reveals microbial diversity and functions in aerobic groundwater microcosms adapted to vinyl chloride. FEMS Microbiology Ecology, 2018, 94 (9), fiy124.
（54） J Liu, R Zhao, J Zhang, G Zhang, K Yu, X Li, B Li. Occurrence and fate of ultramicrobacteria in a full-scale drinking water treatment plant. Frontiers in Microbiology, 2018, 9, 2922.
（55） L Zhou, W Zhuang, X Wang, K Yu, S Yang, S Xia. Potential effects of loading nano zero valent iron discharged on membrane fouling in an anoxic/oxic membrane bioreactor. Water Research, 2017, 111, 140-146.
（56） Y Wang, L Ma, Y Mao, X Jiang, Y Xia, K Yu, B Li, T Zhang. Comammox in drinking water systems. Water Research, 2017, 116, 332-341.
（57） L Zhou, W Zhuang, B Ye, Y Costa, X Wang, K Yu, S Yi, S Yang. Inorganic characteristics of cake layer in A/O MBR for anaerobically digested leachate from municipal solid waste incineration plant with MAP pretreatment. Chemical Engineering Journal, 2017, 327, 71-78.
（58） L Zhou, W Zhuang, X Wang, K Yu, S Yang, S Xia. Potential acute effects of suspended aluminum nitride (AlN) nanoparticles on soluble microbial products (SMP) of activated sludge. Journal of Environmental Sciences, 2017, 57, 284-292.
（59） L Zhou, WQ Zhuang, X Wang, K Yu, S Yang, S Xia. New insights into comparison between synthetic and practical municipal wastewater in cake layer characteristic analysis of membrane bioreactor. Bioresource Technology, 2017, 244, 934-940.
（60） Y Chao, Y Mao, K Yu, T Zhang. Novel nitrifiers and comammox in a full-scale hybrid biofilm and activated sludge reactor revealed by metagenomic approach. Applied Microbiology and Biotechnology, 2016, 100, 8225-8237.
（61） Y Deng, B Li, K Yu, T Zhang. Biotransformation and adsorption of pharmaceutical and personal care products by activated sludge after correcting matrix effects. Science of The Total Environment, 2016, 544, 980-986.
（62） F Guo, Z Wang, K Yu, T Zhang. Detailed investigation of the microbial community in foaming activated sludge reveals novel foam formers. Scientific Reports, 2015, 5 (1), 7637.
（63） Y Mao, K Yu, Y Xia, Y Chao, T Zhang. Genome Reconstruction and Gene Expression of “Candidatus Accumulibacter phosphatis” Clade IB Performing Biological Phosphorus Removal. Environmental Science & Technology, 2014, 48 (17), 10363-10371.
（64） Y Yang, K Yu, Y Xia, FTK Lau, DTW Tang, WC Fung, HHP Fang, T Zhang. Metagenomic analysis of sludge from full-scale anaerobic digesters operated in municipal wastewater treatment plants. Applied Microbiology and Biotechnology, 2014, 98, 5709-5718.
（65） L Cai, K Yu, Y Yang, B Chen, X Li, T Zhang. Metagenomic exploration reveals high levels of microbial arsenic metabolism genes in activated sludge and coastal sediments. Applied Microbiology and Biotechnology, 2013, 97, 9579-9588.
（66） B Chen, Y Yang, X Liang, K Yu, T Zhang, X Li. Metagenomic profiles of antibiotic resistance genes (ARGs) between human impacted estuary and deep ocean sediments. Environmental Science & Technology 2013, 47 (22), 12753-12760.
（67） L Chen, C Huang, C Hu, K Yu, L Yang, B Zhou. Acute exposure to DE‐71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae. Environmental Toxicology and Chemistry, 2012, 31 (10), 2338-2344.
（68） L Yu, J Deng, X Shi, C Liu, K Yu, B Zhou. Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis of zebrafish larvae. Aquatic Toxicology, 2010, 97 (3), 226-233.
（69） J Deng, L Yu, C Liu, K Yu, X Shi, L Yeung, P Lam, R Wu, B Zhou. Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos. Aquatic Toxicology, 2009, 93 (1), 29-36.
（70） Y Du, X Shi, C Liu, K Yu, B Zhou. Chronic effects of water-borne PFOS exposure on growth, survival and hepatotoxicity in zebrafish: a partial life-cycle test. Chemosphere, 2009, 74 (5), 723-729.
（71） C Liu, K Yu, X Shi, J Wang, PKS Lam, RSS Wu, B Zhou. Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromis niloticus). Aquatic Toxicology, 2007, 82 (2), 135-143.
（72） X Yao, F Bao, X Xu, K Yu, B Wu, Y Gao, J Zhang, B Wu etc. The influence of precipitation timing and amount on soil microbial community in a temperate desert ecosystem. Frontiers in Microbiology, 2023,14,1249036.
（73） H Liang, J Huang, Y Tao, U Klümper, TU Berendonk, K Zhou, Y Xia, Y Yang, Y Yu, K Yu etc. Investigating the antibiotic resistance genes and their potential risks in the megacity water environment: A Case Study of Shenzhen Bay Basin, China. Journal of Hazardous Materials, 2024,465(25), 133536.
（74） J Zhang, F Guo, H Liang, K Yu, W Cai, L Lin, X Li, B Li. Unraveling metabolic fate of a veterinary antibiotic thiamphenicol via the multi-omic approach. Chemical Engineering Journal, 2024, 465, 149592.
（75） Z Huang, F Fang, L Ding, K Yu, L Zhang*, H Lu*. Technological Advancements in Field Investigations of Marine Microorganisms: From Sampling Strategies to Molecular Analyses. Journal of Marine Science and Engineering, 2023, 11(10), 1981.
（76） M Zhang, M Kolton, MM Häggblom, X Sun, K Yu etc. Anaerobic ammonium oxidation coupled to arsenate reduction, a novel biogeochemical process observed in arsenic-contaminated paddy soil. Geochimica et Cosmochimica Acta, 2022, 335, 11-22.
（77） Q Wang, C Mao, L Lei, B Yan, J Yuan, Y Guo, T Li, X Xiong, X Cao, J Huang*, J Han, K Yu, B Zhou. Antibiotic resistance genes and their links with bacteria and environmental factors in three predominant freshwater aquaculture modes. Ecotoxicology and Environmental Safety, 2022, 241, 113832.
（78） H He, B Pan*, K Yu, X Zheng, Y Wu, L Xiao, G Zhao, P Zhu. Determinants of bacterioplankton structures in the typically turbid Weihe River and its clear tributaries from the northern foot of the Qinling Mountains. Ecological Indicators, 2021, 121, 107168.
（79） X Huang, J Zhu, Z Cai, Y Lao, H Jin, K Yu, B Zhang, J Zhou. Profiles of quorum sensing (QS)-related sequences in phycospheric microorganisms during a marine dinoflagellate bloom, as determined by a metagenomic approach. Microbiological research, 2018(217), 1-13.
（80） X Shen, R Li, M Chai, K Yu, Q Zan, G Y Qiu. Assessing the effect of extra nitrogen on Kandelia obovata growth under cadmium stress using high-resolution thermal infrared remote sensing and the three-temperature model. Functional Plant Biology, 2018, 45(11), 1162-1171.
（81） JY Zhang, L Liu, G Li, K Yu, P Lv. Oxidative stress effects of chlorpyrifos on zebrafish embryos. China Environmental Science, 2016, 36(3), 927-934.
（82） L Yu, J Deng, X Shi, C Liu, K Yu, B Zhou. Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis of zebrafish larvae. Aquat Toxicol. 2010, 97(3), 226-33.
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